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Abstract #47955 Published in IGR 13-4
(beta)-Zone parapapillary atrophy and the rate of retinal nerve fiber layer thinning in glaucoma
Lee EJ; Kim TW; Weinreb RN; Park KH; Kim SH; Kim DMInvestigative ophthalmology & visual science 2011; 52: 4422-4427
See also comment(s) by Jeffrey Liebmann & Christopher Teng •
To evaluate whether (beta)-zone parapapillary atrophy (PPA) is associated with the rate of retinal nerve fiber layer (RNFL) thickness change as assessed by trend-based analysis using time-domain optical coherence tomography (OCT). This retrospective cohort study included 202 glaucomatous eyes that were observed for (greater-than or equal to)3 years with serial OCTs and stereo disc photographs. Subjects were divided into two groups according to the presence (n = 144) or absence of (beta)-zone PPA (n = 58). The rates of progressive thinning in global, quadrant, and clock-hour OCT RNFL thicknesses were determined using linear regression and compared between groups. Logistic regression analysis was used to determine the factors associated with the rate of global RNFL thinning. The mean rate for global RNFL thinning over time was -1.03 (plus or minus) 1.50 (mu)m/year. Eyes with (beta)-zone PPA showed a significantly faster rate of RNFL thinning than did eyes without (beta)-zone PPA in the inferior quadrant and 7 o'clock sector (values of P < 0.0029). Multivariate analysis showed significant influence of the presence of (beta)-zone PPA and the percentage increase in the PPA to disc area ratio during the follow-up on the rate of OCT RNFL thinning (odds ratio [OR], 3.314, P = 0.007; OR, 2.894, P = 0.003, respectively). Glaucomatous eyes with (beta)-zone PPA are at increased risk for progressive RNFL thinning.
E.J. Lee. Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
Classification:
2.12 Choroid, peripapillary choroid, peripapillary atrophy (Part of: 2 Anatomical structures in glaucoma)
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
