advertisement
Abstract #47976 Published in IGR 13-4
Intrinsically photosensitive (melanopsin) retinal ganglion cell function in glaucoma
Feigl B; Mattes D; Thomas R; Zele AJInvestigative ophthalmology & visual science 2011; 52: 4362-4367
See also comment(s) by Chris Johnson •
To determine whether glaucoma alters intrinsically photosensitive retinal ganglion cell (ipRGC) function. Forty-one patients (25 with glaucoma and 16 healthy age-matched control participants) were tested. Intrinsically photosensitive retinal ganglion cell function was directly measured by the sustained, postillumination pupil response (PIPR). Forty-one eyes of 41 participants were tested with 7(degrees), 10-second, short-wavelength (488 nm; bluish) and long-wavelength (610 nm; reddish) stimuli (14.2 log photons (middle dot) cm(-2) (middle dot) s(-1)) presented to the right eye in Maxwellian view, and the consensual pupil response of the left eye was measured by infrared pupillometry. The difference between PIPR amplitude (percentage baseline pupil diameter), net PIPR (percentage change) and kinetics (time in mm (middle dot) s(-1) to the PIPR plateau) for the blue and red stimuli in patients with early and advanced (moderate/severe) glaucoma was compared to that in age-matched control participants. The blue PIPR was significantly smaller between normal participants and patients with advanced glaucoma, as well as between those with early and those with advanced glaucoma (P < 0.05). The kinetics of the red and blue PIPRs were not significantly different between any groups. Normal age-matched participants and patients with early-stage glaucoma were not significantly different on any parameter, and neither was the normal and glaucoma group (advanced and early combined). Persons with moderate and severe glaucoma have a dysfunctional ipRGC-mediated PIPR. Intrinsically photosensitive retinal ganglion cell function measured directly with the PIPR may become a clinical indicator of progressive changes in glaucoma.
B. Feigl. Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia. Email: b.feigl@qut.edu.au
Classification:
6.6.3 Special methods (e.g. color, contrast, SWAP etc.) (Part of: 6 Clinical examination methods > 6.6 Visual field examination and other visual function tests)