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Abstract #47994 Published in IGR 13-4
Hypotensor bioeffect of laser photobiomodulation over intraocular pressure: Noncomparative interventional case review
Rodriguez-Santana E; Santana-Blank L; Santana-Rodriguez KEJournal of Chinese Clinical Medicine 2011; 6: 1-13
Background Intraocular pressure (IOP) is to date the only modifiable risk factor for glaucoma. This paper reports IOP changes in patients with advanced neoplasias treated with an infrared pulsed laser device (IPLD) in a phase I clinical trial and evaluates potential hypotensor bioeffects of the photo -infrared pulsed biomod-ulation (PIPBM) and water oscillator (WO) mechanisms. Study Design Non-comparative interventional case re -view. Retrospective report. Methods Medical records were selected with the following criteria: At least 1 pre-treat-ment IOP measurement and 1 IOP measurement 3 months post -IPLD treatment taken within 60 min of the time of initial diurnal measurement using a calibrated Goldmann applanation tonometer; absence of ocular macro -metastasis, ocular hypertension, glaucoma, previous ocular surgery, or use of steroids, melatonin or topical ocular medication during treatment. Total daily radiant exposure was 4. 5 null 10(4) J/m(2)/day (power density 4. 5 null 10(4) mW/cm(2)). Main Outcome Measures: Best corrected visual acuity (BCVA) and IOP. Statistical analysis: Student' s t test. Results The charts of 5 patients (n = 10 eyes) met selection criteria (45%). Average age:39 (range:25-59). Sex:2M (40%),3F (60%). A sustained, symmetric IOP drop of 2 mmHg was observed 3 months post-IPLD treatment in OU (P(less-than or equal to)0.0004) remaining under 18 mmHg; no changes were found in BCVA. Conclusion Despite limitations, the clinical and statistical significance of these preliminary data and available mechanistic information suggest an IOP hypotensor effect. Given the clinical safety already documented and the need for effective IOP hypotensor thera -pies with the neuroprotective and vasoprotective features potentially involved, additional ophthalmic research into PIPBM and WO effects over specific targets appears warranted.
E. Rodriguez-Santana. Fundalas, Foundation for Interdisciplinary Research and Development, MUN 1262 Calle Las Flores, C. C. Carabel PB Local 2 Puerto, Estado Anzoategui 6023-1, Venezuela. Email: elizabethroms@gmail.com
Classification:
11.20 Other (Part of: 11 Medical treatment)
