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Abstract #48012 Published in IGR 13-4
Assessing the impact of biomedical research
Gordon M; Holmes KL; Sarli CCClinical and Translational Science 2011; 4: 113
OBJECTIVES/SPECIFIC AIMS: The objective of this study was to assess the impact of a research study on the knowledge base, change in policy and change in practice. METHODS/STUDY POPULATION: We assessed the impact of the Ocular Hypertension Treatment Study (OHTS), a NIH clinical trial that demonstrated the safety and efficacy of ocular hypotensive medication in the prevention of glaucoma. Bibliographic analysis was performed on 26 peer-reviewed journal articles resulting from OHTS. Additional research outputs and activities were also examined to locate evidence of research impact. RESULTS/ANTICIPATED RESULTS: Traditional bibliometric analysis was not sufficiently robust enough to adequately assess the impact of OHTS findings and resulting synthesis into clinical practice. Health outcomes not discernable via bibliometric analysis include practice guidelines, CPT Codes, and curriculum materials, among others. Therefore, we developed a model-based framework rehective of the biomedical research process which included contribution to the knowledge base; change in understanding of a disease; change in policy; change in practice; change in community health; or change in public law or policy. Our framework for assessing the impact of biomedical research has been implemented in a hands-on, web-based site, the Becker Medical Library Model for Assessment of Research Impact. DISCUSSION/ SIGNIFICANCE OF IMPACT: There are a number of resources available to track diffusion of impact above and beyond citation analysis in order to provide a meaningful assessment of policy, practice and health outcomes. The Becker Medical Library Model for Assessment of Research Impact (http://becker.wustl.edu/impact/assessment/) can help biomedical researchers quantify and document translational impact.
M. Gordon. Washington University, School of Medicine, St. Louis, United States.
