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Abstract #48020 Published in IGR 13-4
Corneal biomechanical properties in normal-tension glaucoma
Morita T; Shoji N; Kamiya K; Fujimura F; Shimizu KActa Ophthalmologica 2011;
Abstract.: Purpose: To investigate the intraocular pressure (IOP) and corneal biomechanical properties of normal and normal-tension glaucoma (NTG) eyes. Methods: This study included 83 normal and 83 NTG eyes. We measured corneal-compensated IOP (IOPcc), Goldmann-correlated IOP (IOPg), corneal resistance factor (CRF), corneal hysteresis (CH) and central corneal thickness (CCT) three times each for normal and NTG eyes using an Ocular Response Analyzer (ORA). Results: No significant difference in CCT was seen between normal eyes (541.4(plus or minus)26.8(mu)m) and NTG eyes (535.4(plus or minus)24.9(mu)m; p=0.16). IOPcc was significantly higher in NTG eyes (16.1(plus or minus)2.6mmHg) than in normal eyes (15.1(plus or minus)2.9mmHg; p=0.01), while IOPg was significantly lower in NTG eyes (14.1(plus or minus)2.7mmHg) than in normal eyes (15.1(plus or minus)3.0mmHg; p=0.04). CRF and CH were significantly lower in NTG eyes (CRF, 8.9(plus or minus)1.5mmHg; CH, 9.2(plus or minus)1.3mmHg) than in normal eyes (CRF, 10.6(plus or minus)1.4mmHg; CH, 10.8(plus or minus)1.3mmHg; p<0.0001 each). Conclusion: IOPcc was significantly higher in NTG eyes than in normal eyes. The ORA may be useful for distinguishing between the IOPcc of NTG eyes with normal IOP and that of normal eyes. In addition, the ORA enables CRF and CH to be measured in vivo, and weakness of the lamina cribrosa may be clinically inferred from the fact that CRF and CH were reduced in NTG eyes in our study. Low CRF and CH may be clues to the pathology of NTG. (copyright) 2011 Acta Ophthalmologica Scandinavica Foundation.
T. Morita. Tetsuya Morita, MD, Department of Ophthalmology, Kitasato University School of Medicine, 1-15-1, Kit, . Email: tamosace@gmail.com
Classification:
9.2.4 Normal pressure glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
2.2 Cornea (Part of: 2 Anatomical structures in glaucoma)