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Purpose: To evaluate the acute ocular side effects of Topiramate in patients of migraine. Design: Retrospective study. Materials and Methods: 296 patients of migraine of all ages and of either sex, who were being treated with Topiramate from January 2010 to January 2011 by the neurologist, were retrospectively studied for severe ocular side effects. Results: Four patients of different ages and of either sex reported with signs of shallow anterior chamber, bilateral acute myopia and angle closure glaucoma of varying severity. All four patients responded well to conservative treatment and immediate cessation of Topiramate therapy. Conclusions: Topiramate which is recently being used quite frequently and effectively in the treatment of migraine has rare but potential side effects in the form of bilateral acute angle closure glaucoma which can be effectively managed with prompt stoppage of Topiramate therapy and conservative management.
R. Singla. Department of Ophthalmology, Adesh Medical College and Hospital, Bhatinda, Punjab, India. Email: riteshsingla2k@hotmail.com
9.4.5.5 Other (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.5 Glaucomas associated with disorders of the retina, choroid and vitreous)