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Abstract #48070 Published in IGR 13-4
Effects of antiglaucoma drugs on the ocular surface in rabbits: a fixed-combination drug versus two concomitant drugs
Cho HK; Park MH; Moon JIJapanese Journal of Ophthalmology 2011; 55: 670-675
PURPOSE: We investigated the effects of a fixed-combination antiglaucoma drug and compared it with two concomitant antiglaucoma drugs on the ocular surface. METHODS: Twenty-four rabbits were randomized into four groups. Group 1 was administered timolol, group 2 travoprost, group 3 a travoprost/timolol fixed-combination solution, and group 4 timolol and travoprost. Conjunctival impression cytology specimens were collected at baseline and weeks 1, 3, and 6, and conjunctival biopsy specimens at week 6. RESULTS: The impression cytology study results were as follows: No statistically significant differences among group 1-3 at any time (p > 0.05); a statistically significant difference between groups 3 and 4 at week 6 (p = 0.003); a statistically significant difference between baseline and group 4 at week 6 (p = 0.008). Conjunctival biopsy specimens of group 1-3 showed no distortion of the conjunctival epithelial structures, but group 4 showed decreased layers of epithelial cells with fewer periodic acid-Schiff (PAS) (+) goblet cells. CONCLUSIONS: A fixed-combination antiglaucoma drug is beneficial in reducing adverse ocular surface changes in long-term use. This is believed to be due to the smaller concentration of preservatives contained in the fixed-combination drug.
Department of Ophthalmology and Visual Science, St. Mary's Hospital, The Catholic University of Korea, Yeongdeungpo-gu, Seoul, Korea.
Classification:
11.16 Vehicles, delivery systems, pharmacokinetics, formulation (Part of: 11 Medical treatment)
5.3 Other (Part of: 5 Experimental glaucoma; animal models)
2.1 Conjunctiva (Part of: 2 Anatomical structures in glaucoma)
2.2 Cornea (Part of: 2 Anatomical structures in glaucoma)
