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Abstract #48140 Published in IGR 13-4
A population-based assessment of 24-hour intraocular pressure among subjects with primary open-angle glaucoma: the handan eye study
Wang NL; Friedman DS; Zhou Q; Guo L; Zhu D; Peng Y; Chang D; Sun LP; Liang YBInvestigative Ophthalmology and Visual Science 2011; 52: 7817-7821
See also comment(s) by Tin Aung & Arun Narayanaswamy •
PURPOSE: To describe the distribution of the 24-hour intraocular pressure (IOP) among subjects with primary open-angle glaucoma (POAG) in a population-based study in north China. METHODS: All untreated POAG patients (n = 66) identified in the Handan Eye Study were invited to attend a follow-up study in which IOP was tested with a Goldmann applanation tonometer at 10 AM, 2 PM, 6 PM, 10 PM, 2 AM, and 6 AM. RESULTS: Forty-seven subjects with untreated POAG (47/66; 71.2%) attended the study. Of them, 39 (83.0%) had a peak IOP ≤ 21 mm Hg. The peak IOP (mean ± SD) was 18.4 ± 3.7 mm Hg. Peak IOP occurred in early morning in approximately 76.5% of the subjects (6 AM to 10 AM), and the trough occurred during night time in 70.2% of the subjects (10 PM to 2 AM). The 24-hour IOP (mean ± SD) was 15.4 ± 3.1 mm Hg and the mean fluctuation was 6.0 ± 2.2 mm Hg (range, 2-11 mm Hg). In the 22 persons with unilateral glaucoma, no significant differences were found in mean 24-hour IOP, peak IOP, trough IOP, or IOP fluctuation when comparing the glaucomatous eye with the nonglaucomatous eye (P > 0.05). CONCLUSIONS: About 80% of Chinese persons with POAG identified in a population-based study had maximum IOPs of 21 mm Hg or less over a 24-hour period. Twenty-four-hour IOP was similar between glaucomatous and contralateral nonglaucomatous eyes suggesting that factors other than IOP may play a role in the development of glaucomatous optic neuropathy in these eyes.
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, P.R. China.
Classification:
6.1.2 Fluctuation, circadian rhythms (Part of: 6 Clinical examination methods > 6.1 Intraocular pressure measurement; factors affecting IOP)
