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Abstract #48442 Published in IGR 14-1

Evaluation of peripapillary retinal nerve fiber layer thickness in myopic eyes by spectral-domain optical coherence tomography

Mohammad Salih PA
Journal of Glaucoma 2012; 21: 41-44

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PURPOSE: To investigate the influence of myopia on peripapillary retinal nerve fiber layer (RNFL) thickness using Cirrus optical coherence tomography (OCT) in normal eyes. METHOD: Ninety-eight eyes of normal participants with various degrees of myopia were recruited in this study. The RNFL thickness was measured with high-definition (HD), spectral-domain Cirrus OCT (Cirrus HD-OCT; Carl Zeiss, Dublin, CA). The association between RNFL thickness and its spherical equivalent was evaluated with linear regression analysis. RESULTS: The RNFL thickness was 119.2±16.8 μm, 117.1±16.8 μm, 75.9±16.1 μm, and 64.9±9.8 μm in the superior, inferior, temporal, and nasal quadrants, respectively, with an average thickness of 94.3±8.6 μm. The mean RNFL thickness was thinner in highly and moderately myopic eyes (93±7.9 μm and 92.6±7.7 μm, respectively, P=0.0001) compared with low myopic eyes (102.2±9 μm). A significant linear correlation was found between the spherical equivalent and the RNFL thickness in the superior (r=0.386, P=0.0001) and inferior quadrants (r=0.448, P=0.0001), and the average RNFL thickness (r=0.373, P=0.0001). CONCLUSIONS: Myopia can be a confounding factor in the assessment of RNFL thickness attributed to its influence on the RNFL thickness. Therefore, we recommend a careful interpretation of RNFL data, especially those obtained from eyes with moderate-to-high myopia.

Department of Ophthalmology, International Islamic University Malaysia, Kuantan, Malaysia. paymankurd@yahoo.com

Full article

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Classification:

6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)

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