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Abstract #48543 Published in IGR 14-1
Evaluation of the choroidal thickness using high-penetration optical coherence tomography with long wavelength in highly myopic normal-tension glaucoma
Usui S; Ikuno Y; Miki A; Matsushita K; Yasuno Y; Nishida KAmerican Journal of Ophthalmology 2012; 153: 10-16.e1
See also comment(s) by Tin Aung & Mani Baskaran •
PURPOSE: To evaluate the choroidal thickness by high-penetration optical coherence tomography (OCT) using long wavelength in highly myopic normal-tension glaucoma (NTG). DESIGN: Cross-sectional retrospective study. METHODS: Array SETTINGS: Institutional. PARTICIPANTS: Twelve eyes from 8 patients under 45 years old, diagnosed as NTG without any other ocular diseases, spherical equivalent refractive error between -6 and -12 diopters, and axial length greater than 26.5 mm; and 12 eyes of matched healthy volunteers. INTERVENTION: Choroid was imaged with prototype high-penetration OCT and its thickness was measured. MAIN OUTCOME MEASURES: Choroidal thickness at the fovea and 5 locations: 2 mm superior, temporal, and inferior to the center of the optic nerve head, and 2 mm superior (superotemporal) and 2 mm inferior (inferotemporal) to the temporal location. RESULTS: Overall, the choroidal thickness in the NTG group was approximately 50% that in controls. Mean choroidal thickness in the NTG group was significantly thinner in the control group at the fovea (166 vs 276 μm, P < .001), superior (172 vs 241 μm, P < 0.05), superotemporal (161 vs 244 μm, P < .01), temporal (110 vs 161 μm, P < .01), and inferotemporal (115 vs 159 μm, P < .05) to the optic nerve head. Stepwise analysis disclosed that the foveal choroidal thickness is the most influential factor on the occurrence of NTG (P < .0001, R(2) = 0.4). CONCLUSIONS: Choroidal thickness in highly myopic NTG is significantly thinner than in controls, at least in some specific locations. Choroidal thinning is somehow related with highly myopic NTG and may be a useful diagnostic parameter for myopic NTG.
Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan.
Full articleClassification:
9.2.4 Normal pressure glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
2.12 Choroid, peripapillary choroid, peripapillary atrophy (Part of: 2 Anatomical structures in glaucoma)
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
8.1 Myopia (Part of: 8 Refractive errors in relation to glaucoma)
