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Abstract #48809 Published in IGR 14-1
Genome-wide association studies in the hunt for genes causing primary open angle glaucoma
Burdon KPClinical and Experimental Ophthalmology 2012; 40: 358-363
Genome-wide association studies are a powerful tool for the identification of genetic risk factors for complex disease. This methodology has been successfully applied to primary open-angle glaucoma through the analysis of POAG itself as well as specific subgroups of patients including those with Normal Tension Glaucoma and Advanced Glaucoma. In addition, the analysis of quantitative traits important in POAG, including optic disc area and vertical cup-to-disc ratio has also identified genes important in POAG development. This review explores findings of genome-wide association studies for POAG and related traits.
Department of Ophthalmology, Flinders University, Adelaide, SA, Australia.
Full articleClassification:
3.4.2 Gene studies (Part of: 3 Laboratory methods > 3.4 Molecular genetics)
3.4.1 Linkage studies (Part of: 3 Laboratory methods > 3.4 Molecular genetics)
