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Abstract #49040 Published in IGR 14-1
The influence of central corneal thickness on response to topical prostaglandin analogue therapy
Birt CM; Buys YM; Kiss A; Trope GE;Canadian Journal of Ophthalmology 2012; 47: 51-54
OBJECTIVE: Central corneal thickness (CCT) affects intraocular pressure (IOP) readings; however, CCT influence on topical medication efficacy is unknown. We evaluated the IOP-lowering effect of topical prostaglandin analogues (PGAs) in relation to CCT. DESIGN: Post hoc analysis of a randomized prospective trial. METHOD: Subjects randomized to a PGA were followed for 24 weeks and were analyzed for relationship between CCT and IOP lowering. PARTICIPANTS: Patients with either newly diagnosed ocular hypertension or open-angle glaucoma. RESULTS: 75 subjects were enrolled. The mean age was 62.7 ± 10.5 years; 48 were Caucasian. The mean CCT was 562.4 ± 41.4 μ. At repeated measures, ANCOVA analysis showed a significant effect of both baseline IOP (p < 0.0001) and CCT (p = 0.003) on IOP. At week 12, a regression analysis of the effect of CCT on baseline IOP showed that for every 10 μ increase in CCT there was 0.3 mm Hg less IOP decrease from baseline. CONCLUSIONS: We found a statistically significantly association between a lower mean IOP and a thinner cornea when baseline IOP is controlled for. The magnitude of the relationship is small but may be clinically significant in patients with either very thin or very thick corneas.
Department of Ophthalmology & Vision Sciences, University of Toronto, Toronto, Ont. catherine.birt@sunnybrook.ca
Full articleClassification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
2.2 Cornea (Part of: 2 Anatomical structures in glaucoma)
