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Abstract #49154 Published in IGR 14-1
Prevalence of signs and symptoms of ocular surface disease in individuals treated and not treated with glaucoma medication
O',Hare F; Ghosh S; Lamoureux E; Vajpayee RB; Crowston JGClinical and Experimental Ophthalmology 2012; 40: 675-681
BACKGROUND: To determine the prevalence of signs and symptoms of ocular surface disease in two hospital based cohorts; glaucoma patients and non-glaucoma patients. DESIGN: A cross sectional, comparative case series. PARTICIPANTS: Glaucoma patients (n = 300) prescribed topical glaucoma medications for ≥ 6 months were compared to control patients (n=100) who were not applying prescribed topical medications. METHODS: A validated self-report questionnaire was used to elicit the extent of ocular symptoms. Signs of ocular surface and eyelid disease were assessed along with medication history. Main outcome measures: Signs and symptoms of ocular surface pathology were determined including the tear film break-up time (TBUT), fluorescein staining of the cornea and conjunctiva, meibomian gland dysfunction (MGD) and Schirmer test. RESULTS: A significant increase in the prevalence of OSD signs was observed in the glaucoma population, 70.3%, compared to controls, 33% (p <0.001). The overall prevalence of clinically significant OSD symptoms was not significantly different between cohorts, 30.7% versus 24.0% respectively (p = 0.252). Logistic regression analysis showed that the number of anti-glaucoma medications and duration of therapy were key predictors of significant OSD signs in the glaucoma group. There was no significant correlation between signs and symptoms of OSD in either group after adjusting for age and gender. CONCLUSIONS: Signs and symptoms of OSD are relatively common in older patients but signs of OSD are significantly higher in individuals who instill topical glaucoma therapy.
Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, 32 Gisborne St, East Melbourne, Victoria, Australia.
Full articleClassification:
2.1 Conjunctiva (Part of: 2 Anatomical structures in glaucoma)
11.16 Vehicles, delivery systems, pharmacokinetics, formulation (Part of: 11 Medical treatment)