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Abstract #49197 Published in IGR 14-1
Glaucoma Diagnostic Ability of Quadrant and Clock-Hour Neuroretinal Rim Assessment Using Cirrus HD Optical Coherence Tomography
Hwang YH; Kim YYInvestigative Ophthalmology and Visual Science 2012; 53: 2226-2234
PURPOSE: The aim of this study was to investigate the glaucoma diagnostic ability of quadrant and clock-hour neuroretinal rim assessment by Cirrus HD spectral-domain optical coherence tomography (OCT). METHODS: Eighty eyes of 80 glaucoma patients and 80 eyes of 80 healthy subjects were enrolled. Peripapillary retinal nerve fiber layer (RNFL) thickness was measured by Cirrus HD-OCT. Quadrant and clock-hour rim areas and thicknesses were obtained from optic nerve head images and 360° circumferential rim thickness curve of Cirrus HD-OCT, respectively. Area under receiver operating characteristic curves (AUCs) and sensitivities of RNFL thicknesses, rim areas, and rim thicknesses at a 90% specificity level were calculated. RESULTS: Quadrant and clock-hour rim area and thickness showed good diagnostic ability for glaucoma in all areas (AUCs, 0.877-0.969; sensitivities, 67.5%-96.3%). When the AUCs of RNFL thicknesses, rim areas, and rim thicknesses were compared, no significant difference was found in global area and superior and inferior quadrants (P > 0.05). However, in nasal and temporal quadrants, rim area and thickness had greater AUCs (AUCs, 0.919-0.945; sensitivities, 82.5%-86.3%) than RNFL thickness (AUCs, 0.749-0.776; sensitivities, 12.5%-33.8%; P < 0.001). Eyes with moderate to advanced glaucoma (mean deviation < -6 dB) had thinner RNFL than mild glaucoma (mean deviation ≥ -6 dB) in global area, superior, inferior, and temporal quadrants (P < 0.003); rim area and thickness showed no significant difference in all areas (P > 0.003). CONCLUSIONS: Neuroretinal rim assessment in nasal and temporal areas by Cirrus HD-OCT may enhance glaucoma diagnostic ability. RNFL and rim changes measured by Cirrus HD-OCT may be different according to the stages of glaucomatous damage.
Department of Ophthalmology, Konyang University, Kim's Eye Hospital, Myung-Gok Eye Research Institute, Seoul, Korea; Department of Ophthalmology, Armed Forces Capital Hospital, Seongnam, Korea.
Full articleClassification:
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)
