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Abstract #49239 Published in IGR 14-1
Association between corneal biomechanical properties and optic nerve head morphology in newly diagnosed glaucoma patients
Prata TS; Lima VC; Guedes LM; Biteli LG; Teixeira SH; De Moraes CG; Ritch R; Paranhos AClinical and Experimental Ophthalmology 2012; 40: 682-688
BACKGROUND: To investigate the association between corneal biomechanical properties and optic nerve head (ONH) morphology in newly diagnosed primary open-angle glaucoma (POAG) patients. DESIGN: Hospital-based prospective study. PARTICIPANTS: Forty-two untreated newly diagnosed POAG patients [intraocular pressure (IOP)>21mmHg]. METHODS: Patients underwent corneal hysteresis (CH) measurement using the Ocular Response Analyzer and confocal scanning laser ophthalmoscopy for ONH topography evaluation. One eye was selected randomly for analysis. Data collected included age, race, gender, IOP and central corneal thickness (CCT). MAIN OUTCOME MEASURES: Multiple regression analysis (controlling for baseline IOP and disc area) was used to investigate factors associated with the following ONH topographic parameters: linear cup-to-disc ratio (CDR) and mean cup depth (MCD). RESULTS: Mean age of participants was 66.7 ± 11.8 years. CH was the only factor significantly associated with both MCD (r = -0.34, p = 0.03) and CDR (r = -0.41, p = 0.01). CCT was significantly associated with MCD (r = -0.35, p = 0.02), but not with CDR (r = -0.25, p = 0.13). Although a trend toward a positive association between age and CDR was identified (r = 0.26, p = 0.08), age was not significantly associated with MCD (r = 0.06, p = 0.72). No significant associations were found for race (p ≥ 0.62). When comparing fellow eyes of patients with bilateral POAG, the eye with higher CH had smaller CDR in 75% of the cases. CONCLUSIONS: In untreated newly diagnosed POAG patients, those with thinner corneas and mainly lower CH values had a larger cup-to-disc ratio and deeper cup (independently of IOP values and disc size). Whether these observations imply in a direct relationship between these corneal parameters and ONH susceptibility to glaucomatous damage deserves further investigation.
Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil.
Full articleClassification:
2.2 Cornea (Part of: 2 Anatomical structures in glaucoma)
12.4 Laser trabeculoplasty and other laser treatment of the angle (Part of: 12 Surgical treatment)
6.1.1 Devices, techniques (Part of: 6 Clinical examination methods > 6.1 Intraocular pressure measurement; factors affecting IOP)
6.9.1.1 Confocal Scanning Laser Ophthalmoscopy (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.1 Laser scanning)
