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Abstract #49250 Published in IGR 14-1
Contrast-response functions of the multifocal steady-state VEP (MSV)
Abdullah SN; Vaegan; Boon MY; Maddess TClinical Neurophysiology 2012; 123: 1865-1871
OBJECTIVES: To measure contrast-response functions (CRFs) for 9 visual field (VF) regions and nonlinear interactions between regions using a multifocal steady-state VEP (MSV). METHODS: Ten normal adults were tested (51.7±16.9yr, 5 females). Stimuli resembling those of the Frequency Doubling Technology (FDT) perimeter were presented in 9 VF regions simultaneously, which were modulated at incommensurate temporal frequencies (mean 19.7Hz). Responses were recorded to 11 contrasts from 3% to 89%, using 8 scalp electrodes. Two repeats of a 20s duration stimulus were averaged for each contrast. RESULTS: The CRFs were log-linear except for a depression near 7% contrast (p=0.0008), which was prominent in the central VF. The effects of VF region, stimulus frequency and recording electrode were significant (all p<0.016). Significant responses at frequencies corresponding to interactions between VF regions also appeared. Electrodes that were best for the interactions and second harmonic responses differed, suggesting different cortical sources. CONCLUSIONS: Despite short recording durations the saturating CRFs meant that significant responses could be measured to low contrasts, and be distinguished from nonlinear interactions. SIGNIFICANCE: Recording MSVs to low contrast FDT-like stimuli might be useful for quantifying damage by glaucoma and other visual disorders.
School of Optometry and Vision Science, University of New South Wales, Sydney, Australia.
Full articleClassification:
6.7 Electro-ophthalmodiagnosis (Part of: 6 Clinical examination methods)
