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Miscellaneous (20)

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Abstract #49983 Published in IGR 14-2

Lack of association between polymorphisms in the prostaglandin F(2α) receptor and solute carrier organic anion transporter family 2A1 genes and intraocular pressure response to prostaglandin analogs

McCarty CA; Berg R; Patchett R; Wilke RA; Burmester JK
Ophthalmic Genetics 2012; 33: 74-76

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PURPOSE: To evaluate the association between variants in the prostaglandin F(α) receptor (PTGFR) and solute carrier organic anion transporter family 2A1 (SLCO2A1) genes and intraocular pressure (IOP) response to prostaglandin analogs. METHODS: The medical records of subjects with previously diagnosed open angle glaucoma or ocular hypertension were searched for intraocular pressure measurements before and after prescriptions of prostaglandin analogs. Stored DNA samples were genotyped for the following SNPs: rs3753380 (promoter region) and rs3766355 (intronic region) of the prostaglandin F(2α) receptor gene, and rs34550074 (Ala396Thr) of SLCO2A1. The mean change in IOP by genotype was measured. RESULTS: Prostaglandin analogs were prescribed to 267 subjects; 242 (204 right eyes, 205 left eyes) met the inclusion/exclusion criteria for the current study. There was no significant association between genotype and IOP response to prostaglandin analogs (p = 0.48, p = 0.54, p = 0.90). CONCLUSION: In summary, we found no indication for an association between SNPs in the prostaglandin F(2α) receptor gene or SLCO2A1 and IOP response to prostaglandin analogs in a population of European descent.

Marshfield Clinic Research Foundation , Marshfield , USA.

Full article

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Classification:

11.4 Prostaglandins (Part of: 11 Medical treatment)
3.4.2 Gene studies (Part of: 3 Laboratory methods > 3.4 Molecular genetics)
3.8 Pharmacology (Part of: 3 Laboratory methods)

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