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Abstract #50302 Published in IGR 14-2
Risk factors for progression of normal-tension glaucoma under β-blocker monotherapy
Araie M; Shirato S; Yamazaki Y; Matsumoto C; Kitazawa Y; Ohashi Y;Acta Ophthalmologica 2012; 90: e337-e343
PURPOSE: To prospectively study prognostic factors for normal-tension glaucoma (NTG) under treatment with topical β-blocker. METHODS: One hundred and forty-six eyes of 146 patients with NTG with a mean untreated intraocular pressure (IOP) of 14 mmHg, mild to moderate visual field damage and mean spherical equivalent refraction of -3.5 (-8.0 to +2.0) dioptre were randomized to topical nipradilol or timolol and followed for 3 years. The Humphrey full threshold 30-2 visual field test was performed every 6 months, and optic disc photographs were obtained every 12 months. Progression was defined as visual field progression, optic disc and/or peripapillary nerve fibre layer change, and factors relating to progression were evaluated using Cox proportional hazards models. RESULTS: IOP decreased by 1.0 mmHg over the 3-year period, during which 35% showed progression according to the aforementioned criteria. Optic disc haemorrhage (hazard ratio [HR] 4.00, p < 0.001) and less extent of myopia (per dioptre, HR 1.15, p = 0.013) were significant risk factors. When progression was defined by visual field progression only, less extent of myopia was again a significant risk factor (HR 1.17, p = 0.038). CONCLUSION: Beside optic disc haemorrhage, less extent of myopia was a risk factor for progression in the current NTG population where most patients were mildly myopic and IOP during follow-up averaged 13.2 mmHg under topical β-blocker.
Kanto Central Hospital, Tokyo, Japan Yotsuya-Shirato Eye Clinic, Tokyo, Japan Department of Ophthalmology, Nihon University School of Medicine, Tokyo, Japan Department of Ophthalmology, Kinki University School of Medicine, Osaka, Japan Gifu University, Gifu, Japan Department of Biostatistics, School of Public Health, University of Tokyo, Tokyo, Japan.
Full articleClassification:
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
9.2.4 Normal pressure glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
6.20 Progression (Part of: 6 Clinical examination methods)
6.6.2 Automated (Part of: 6 Clinical examination methods > 6.6 Visual field examination and other visual function tests)
