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Abstract #50808 Published in IGR 14-3
Effects of corneal thickness on the intraocular penetration of travoprost 0.004%
Martinez-de-la-Casa JM; Rayward O; Saenz-Frances F; Santos-Bueso E; Mendez-Hernandez C; Herrero-Vanrell R; Garcia-Feijoo J; Garcia-Sanchez JEye 2012; 26: 972-975
PURPOSE: To determine whether the intraocular penetration of travoprost 0.004% is affected by central corneal thickness. METHODS: Sixty-four patients who were scheduled for cataract surgery without any other ophthalmologic pathology of significance were enrolled in this study. At 120 min before surgery, one drop of travoprost 0.004% was instilled in the eye to be operated on. At the start of surgery, a sample of aqueous humour was extracted to subsequently determine its AL-5848 concentration. These concentrations were compared among three groups of patients established according to central corneal thickness measurements obtained by ultrasound pachymetry. RESULTS: Mean AL-5848 concentrations were 3.27±2.03 ng/ml in Group I (CCT<511 microns), 3.27±2.44 ng/ml in Group II (CCT≥511 and ≤574 microns), and 2.73±2.15 ng/ml in Group III (CCT>574 microns), indicating no significant differences among the groups. CONCLUSIONS: We were unable to demonstrate the greater or lesser penetration of travoprost depending on corneal thickness, which could explain differences in patient responses to this drug.
Servicio de Oftalmologia, Hospital Clinico San Carlos, Departamento de Oftalmologia, Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos, Madrid, Spain. martinezcasa@ya.com
Full articleClassification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
2.2 Cornea (Part of: 2 Anatomical structures in glaucoma)
