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Abstract #51230 Published in IGR 14-3
Longitudinal effect of topical antiglaucoma medications on central corneal thickness
Viswanathan D; Goldberg I; Graham SLClinical and Experimental Ophthalmology 2013; 41: 348-354
BACKGROUND: To determine the change in central corneal thickness (CCT) over time and whether use of long term topical antiglaucoma medications influences CCT. DESIGN: Case control study with retrospective and prospective data collection PARTICIPANTS: 187 eyes of 187 glaucoma patients (mean follow up 6.92 ± 1.67 years) being treated with topical antiglaucoma medications (at least 3 years) with no history of surgery or laser were included and compared with 100 eyes of 100 age matched untreated control subjects (mean follow up 6.58 ± 1.93 years) who were glaucoma suspects with normal intraocular pressure (IOP) not on any treatment. METHODS: Demographic data, CCT and IOP were collected at initial glaucoma diagnosis and at most recent visit and findings were compared between two groups. MAIN OUTCOME MEASURES: Mean change in CCT in microns (μm) RESULTS: CCT fell significantly (p < 0.0001) in treated eyes but not in control eyes (p = 0.18) , mean CCT reduction was 12.29 ± 13.65 μm in treated eyes and 1.17 ± 8.75 μm in controls. Amongst treated eyes, CCT reduction was significant (p < 0.0001) in those treated with either prostaglandins or a combination of prostaglandin and betablockers, while no significant reduction occurred in eyes treated with only betablockers ( p = 0.15) when compared with control eyes. CONCLUSIONS: Prostaglandins appear to be associated with a small but significant CCT reduction over time. Serial CCT measurements might be helpful in glaucoma patients, particularly those on prostaglandins.
Australian School of Advanced Medicine, Macquarie University, Sydney, Australia.
Full articleClassification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
11.13.4 Betablocker and prostaglandin (Part of: 11 Medical treatment > 11.13 Combination therapy)
2.2 Cornea (Part of: 2 Anatomical structures in glaucoma)
