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Abstract #51232 Published in IGR 14-3
Optometry-based general population survey of pupil ruff atrophy and ocular hypertension
Ang GS; Stevenson PJ; Sargent G; Grimmer P; Corbett P; Jourdain E; Wells APClinical and Experimental Ophthalmology 2013; 41: 360-367
BACKGROUND: To evaluate and describe the pupil ruff changes and relationship to intraocular pressure (IOP), pseudoexfoliation syndrome (PXF) and glaucoma status in an optometric population in New Zealand DESIGN: Prospective cross-sectional survey of an optometric population PARTICIPANTS: 620 subjects over 50 years old routinely attending the participating optometry practices. Exclusion criteria included previous intraocular surgery, ophthalmic laser, uveitis, iris neovascularization, angle closure on gonioscopy and secondary glaucoma. METHODS: Multi-center study involving 11 optometry practices in the Wellington region, New Zealand. The pupillary ruff and associated gonioscopy findings of study participants were graded based on the previously published Pupil Ruff Atrophy (PRA) grading system. Parameters evaluated include pupillary ruff absence and abnormality, PXF material, and trabecular meshwork pigmentation. MAIN OUTCOME MEASURES: Correlations between inter-eye PRA grading differences and inter-eye IOP and CDR differences. RESULTS: 620 subjects were included, with a mean age of 62.2 ± 9.1 years and mean IOP of 14.8 ± 3.4 mmHg. 414 (66.8%) had bilateral pupil ruff changes and 12 (1.5%) had PXF. Inter-eye IOP asymmetry was significantly correlated with amount of missing pupillary ruff (r = 0.111; P = 0.022) and trabecular meshwork pigmentation (r = 0.147; P = 0.002). Inter-eye CDR asymmetry was not correlated with any of the PRA grading parameters. CONCLUSIONS: Asymmetry of pupillary ruff absence and trabecular meshwork pigmentation was correlated with IOP asymmetry (but not with CDR asymmetry) in a general optometric population setting in New Zealand. Further study will be required to determine the clinical relevance of this finding.
Capital Eye Specialists, Wellington, New Zealand.
Full articleClassification:
2.8 Iris (Part of: 2 Anatomical structures in glaucoma)
9.4.4.1 Exfoliation syndrome (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.4 Glaucomas associated with disorders of the lens)
9.2.1 Ocular hypertension (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)