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Abstract #51300 Published in IGR 14-3
In vivo imaging of retinal ganglion cell apoptosis
Galvao J; Davis BM; Cordeiro MFCurrent opinion in pharmacology 2013; 13: 123-127
Apoptosis, or programmed cell death, plays a vital role in normal development and ageing. However, dysregulation of this process is responsible for many disease states including; cancer, autoimmune and neurodegeneration. For this reason, in vivo visualisation of apoptosis may prove a useful tool for both laboratory research and clinical diagnostics. Glaucoma comprises a distinctive group of chronic optic neuropathies, characterised by the progressive loss of retinal ganglion cells (RGCs). Early diagnosis of glaucoma remains a clear and unmet need. Recently, there have been significant advances in the detection of apoptosis in vivo using fluorescent probes to visualise single RGCs undergoing apoptosis, specifically DARC (Detection of Apoptotic Retinal Cells) [1] and capQ technology [2(••)].
Glaucoma & Retinal Neurodegeneration Research Group, University College London, London EC1 V9EL, UK.
Full articleClassification:
3.13.3 RGC Imaging (Part of: 3 Laboratory methods > 3.13 In vivo imaging)
11.8 Neuroprotection (Part of: 11 Medical treatment)
