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Abstract #5158 Published in IGR 1-2
Dominant inheritance of chronic open-angle glaucoma in an Algerian family
Ouhadj O; Degheb N; Nouri MTJournal Français d'Ophtalmologie 1999; 22: 571-576
BACKGROUND: The hereditary nature of chronic open-angle glaucoma (COAG) is recognized in 20 to 25 % of the cases. Disease prevalence among relatives of patients with glaucoma is higher than in the general population. Several inheritance modes may co-exist. METHOD: Forty-seven members of a family living in eastern Algeria were studied. Three generations were examined. RESULTS: There were 15 cases of COAG (8 men and 7 women) in this family, i.e. 32 % of the members. Affected members were aged from 23 to 80 years. DISCUSSION: An epidemiologic, clinical and genetic analysis of this family provided information concerning the transmission modes of COAG. CONCLUSION: It is highly likely that in this family, COAG was transmitted by autosomal dominant inheritance with strong penetrance. Genetic analysis excluded locus GLC1A mutation, confirming the heterogeneous nature of COAG inheritance.
O. Ouhadj, 8, rue Mouloud Zadi, 16016 Alger; Algeria
Classification:
1.2 Population genetics (Part of: 1 General aspects)
