advertisement
Abstract #5161 Published in IGR 1-2
A novel gene (oculomedin) induced by mechanical stretching in human trabecular cells of the eye
Sato Y; Matsuo T; Ohtsuki HBiochemical and Biophysical Research Communications 1999; 259: 349-351
To understand molecular mechanisms underlying the response to pressure in human trabecular cells of the eye, genes induced by cyclic mechanical stretching were isolated by subtractive hybridization assisted by polymerase chain reaction. A novel gene containing an Alu repetitive element in the 5' untranslated region was identified, and its expression was confirmed by Northern blot analysis to be stretch-specific in trabecular cells. The gene was also expressed in the retina, but not in the other tissues, including the brain. The gene encoded a putative small protein with 44 amino acids, which showed homology with neuromedin K. The putative novel protein was named as "oculomedin," and would be used as a candidate gene for glaucoma. Copyright 1999 Academic Press.
Department of Ophthalmology, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama City, 700-8558, Japan.
Classification:
1.2 Population genetics (Part of: 1 General aspects)