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Abstract #51661 Published in IGR 14-4
HIF-1 expression in retinal ganglion cells and optic nerve axons in glaucoma
Reszeć J; Zalewska R; Bernaczyk P; Chyczewski LFolia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society 2012; 50: 456-459
Glaucoma is a result of increased intraocular pressure leading to damage to retinal ganglion cells and optic nerve axons. The aim of this study was to evaluate HIF-1 expression in optic nerve axons and retinal ganglion cells in 42 eyes enucleated because of complete glaucoma compared to eyes removed because of injury.The immunohistochemical reaction was done and specimens were examined under a light microscope. 57% of cases presented HIF-1 expression in the optic nerve axons, and 52.3% in the retinal ganglion cells. 20 out of 42(47.6%) cases were HIF-1 positive both in the optic nerve axons and in the retinal ganglion cells, and the staining was evident mostly in the nuclear and perinuclear area. Our present results indicate that HIF-1 expression in hypoxic conditions in glaucoma might be a very crucial stage in damage to retinal ganglion cells and optic nerve axons, and might be a successful target for the implementation of neuroprotective drugs.
Department of Medical Pathomorphology, Medical University of Bialystok, Poland. joasia@umb.edu.pl
Full articleClassification:
3.3 Immunohistochemistry (Part of: 3 Laboratory methods)
2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)
2.15 Optic nerve (Part of: 2 Anatomical structures in glaucoma)
3.9 Pathophysiology (Part of: 3 Laboratory methods)
