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1 General aspects (0)   1.1 Epidemiology (9)   1.2 Population genetics (2)   1.3 Pathogenesis (3)   1.4 Quality of life (5)   1.5 Glaucomas as cause of blindness (6)   1.6 Prevention and screening (7) 2 Anatomical structures in glaucoma (0)   2.1 Conjunctiva (8)   2.2 Cornea (15)   2.3 Sclera (4)   2.4 Anterior chamber angle (8)   2.5 Meshwork (0)     2.5.1 Trabecular meshwork (7)     2.5.2 Schlemms canal (2)     2.5.3 Scleral outlet channels (0)   2.6 Aqueous humor dynamics (0)     2.6.1 Production (0)     2.6.2 Outflow (0)       2.6.2.1 Trabecular meshwork (1)       2.6.2.2 Uveoscleral (0)     2.6.3 Compostion (3)   2.7 Episcleral veins and venous pressure (1)   2.8 Iris (2)   2.9 Ciliary body (1)   2.10 Lens (0)   2.11 Vitreous body (0)   2.12 Choroid, peripapillary choroid, peripapillary atrophy (5)   2.13 Retina and retinal nerve fibre layer (18)   2.14 Optic disc (19)   2.15 Optic nerve (2)   2.16 Chiasma and retrochiasmal central nervous system (3)   2.17 Stem cells (2)   2.20 Other (0) 3 Laboratory methods (0)   3.1 Microscopy (2)   3.2 Electron microscopy (0)   3.3 Immunohistochemistry (1)   3.4 Molecular genetics (0)     3.4.1 Linkage studies (5)     3.4.2 Gene studies (21)   3.5 Molecular biology incl. 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Miscellaneous (13)

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Abstract #51793 Published in IGR 14-4

Endothelial Graft Failure After Contralateral Autologous Corneal Transplantation

Martinez JD; Galor A; Perez VL; Karp CL; Yoo SH; Alfonso EC
Cornea 2013; 32: 745-750

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PURPOSE: To report on outcomes after contralateral autologous penetrating keratoplasty (APK). DESIGN: Case series. PATIENT POPULATION: Five patients who received a contralateral APK and a simultaneous allogeneic penetrating keratoplasty in the donor eye at the Bascom Palmer Eye Institute and the Miami Veterans Affairs Hospital. RESULTS: The median patient age at the time of surgery in our 5 patients was 67 years (range, 58-88 years); 4 patients were male and 1 female, and 1 patient was white and 4 were black. The surgery was uneventful in all cases, and no operative or immediate postoperative complications occurred in either eye. Follow-up time ranged from 18 to 54 months (mean, 35 months; median, 34 months). During this time, 4 of the autologous grafts failed because of endothelial attenuation. Identified risk factors for failure in the autologous eyes included the presence of a glaucoma tube (5/5), previous graft failure (4/5), and anterior synechiae (2/5). CONCLUSIONS: This study is the first to describe graft failure because of slow endothelial attenuation after APK. This study underscores the importance of nonimmunologic factors in endothelial cell loss after corneal transplant surgery and highlights the need for further research to understand and modulate endothelial loss.

*Surgical Division, Miami Veterans Administration Medical Center, Miami, FL †Cornea and External Diseases division, Bascom Palmer Eye Institute, University of Miami, Miami, FL.

Full article

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Classification:

9.4.11.4 Glaucomas associated with corneal surgery (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.11 Glaucomas following intraocular surgery)
12.8.2 With tube implant or other drainage devices (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
2.2 Cornea (Part of: 2 Anatomical structures in glaucoma)
12.8.11 Complications, endophthalmitis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)

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