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Abstract #51955 Published in IGR 14-4
Recovery from deepening of the upper eyelid sulcus after switching from bimatoprost to latanoprost
Sakata R; Shirato S; Miyata K; Aihara MJapanese Journal of Ophthalmology 2013; 57: 179-184
See also comment(s) by Stanley Berke •
PURPOSE: Although useful for reducing intraocular pressure (IOP), bimatoprost (BIM) can cause deepening of the upper eyelid sulcus (DUES), one of the symptoms of prostaglandin-associated periorbitopathy (PAP). We investigated recovery from BIM-induced DUES after switching treatment to latanoprost (LAT). DESIGN: Prospective, observer-masked, open-label study. METHODS: Twenty-five Japanese patients suffering from primary open-angle glaucoma treated with LAT in both eyes for longer than 6 months and requiring further IOP reduction were prospectively enrolled in the study. During the first 6 months after the switch to BIM, 15 of the 25 patients (60 %) developed DUES. Among these patients, 13 were switched back to LAT and re-examined for DUES at 2-month intervals for an additional 6 months. RESULTS: Two months after the switch back to LAT, for 11 of the 13 patients (85 %) the DUES symptoms had either decreased or disappeared, and this was maintained for at least 6 months. During this time, 6 of 8 patients (75 %) subjectively positive for DUES self-reported a decrease in DUES. CONCLUSIONS: Although DUES is a frequent side effect of treatment with BIM, switching to LAT may reverse the condition for most patients.
Department of Ophthalmology, Tokyo Metropolitan Geriatric Hospital, 35-2 Sakaecho, Itabashi, Tokyo, 173-0015, Japan, reisakata-tky@umin.ac.jp.
Full articleClassification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
