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Abstract #52373 Published in IGR 15-1
Ocular Hypertension and the Risk of Blindness
Gestel AV; Webers CA; Beckers HJ; Peeters A; Severens JL; Schouten JSJournal of Glaucoma 2015; 24: 9-11
PURPOSE: To estimate the risk of blindness in patients with ocular hypertension (OHT) using an appropriate model and current empirical data. DESIGN: A Markov model with data from a systematic literature review. METHODS: A Markov model with 3 health states was built: OHT, primary open-angle glaucoma (POAG), and unilateral blindness. Literature was searched for reports on conversion from OHT to POAG and progression from POAG to blindness, to estimate a range of annual conversion and progression probabilities. The model had a cycle length of 1 year. RESULTS: The 15-year risk estimates ranged from 3.1% to 9.4% in untreated, and from 0.9% to 8.6% in treated patients with OHT. The ranges were the result of differences in patient populations, treatments, and outcome definitions in currently available empirical data. CONCLUSIONS: The best estimates of the 15-year risk of unilateral blindness in patients with OHT, based on the currently available empirical data and an appropriate model, show that the risk is <10%.
*University Eye Clinic †Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Center, Maastricht ‡Institute of Health Policy and Management, Erasmus University, Rotterdam, The Netherlands.
Full articleClassification:
1.5 Glaucomas as cause of blindness (Part of: 1 General aspects)
9.2.1 Ocular hypertension (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
