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Abstract #52398 Published in IGR 15-1
Qualitative Evaluation of the Iris and Ciliary Body by Ultrasound Biomicroscopy in Subjects With Angle Closure
Ku JY; Nongpiur ME; Park J; Narayanaswamy AK; Perera SA; Tun TA; Kumar RS; Baskaran M; Aung TJournal of Glaucoma 2014; 23: 583-588
PURPOSE: To qualitatively analyze anterior chamber structures imaged by ultrasound biomicroscopy (UBM) in primary angle-closure patients. METHODS: Subjects diagnosed as primary angle-closure suspect (PACS), primary angle-closure glaucoma (PACG), and previous acute primary angle closure (APAC) were recruited prospectively along with a group of normal controls. UBM was performed under standardized dark room conditions and qualitative assessment was carried out using a set of reference photographs of standard UBM images to categorize the various anatomic features related to angle configuration. These included overall and basal iris thicknesses, iris convexity, iris angulation, ciliary body size, and ciliary sulcus. RESULTS: A total of 60 PACS, 114 PACG, 41 APAC, and 33 normal controls were included. Patients were predominantly older Chinese females. After controlling the confounding effect of age and sex, eyes with overall thicker irides [medium odds ratio (OR) 3.58, thick OR 2.84] when compared with thin irides have a significantly higher likelihood of having PACS/PACG/APAC versus controls. Thicker basal iris component (medium OR 4.13, thick OR 3.39) also have higher likelihood of having angle closure when compared with thin basal iris thickness. Subjects with basal iris insertion, mild iris angulation, and large ciliary body have a higher OR of having angle closure. In contrast, the presence/absence of a ciliary sulcus did not influence the likelihood of angle closure. CONCLUSIONS: Eyes with thicker overall and basal iris thicknesses are more likely to have angle closure than controls. Other features that increase the likelihood of angle closure include basal iris insertion, mild iris angulation, and large ciliary body.
*Singapore National Eye Centre & Singapore Eye Research Institute ‡Yong Loo Lin School of Medicine, National University of Singapore, Singapore †Narayana Nethralaya, Bangalore, India.
Full articleClassification:
9.3.5 Primary angle closure (Part of: 9 Clinical forms of glaucomas > 9.3 Primary angle closure glaucomas)
6.12 Ultrasonography and ultrasound biomicroscopy (Part of: 6 Clinical examination methods)
2.8 Iris (Part of: 2 Anatomical structures in glaucoma)
2.9 Ciliary body (Part of: 2 Anatomical structures in glaucoma)
