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Abstract #5241 Published in IGR 1-2
Superior cervical ganglionectomy-induced lowering of intraocular pressure in rabbits: role of prostaglandins and neuropeptide Y.
Zhan GL; Ohia SE; Camras CB; Ohia EO; Wang YLGeneral Pharmacology 1999; 32: 189-194
At 22-24 h after unilateral ganglionectomy (SX), intraocular pressure (IOP) was significantly (p < 0.001) reduced in SX eyes compared either with the contralateral, normally innervated eyes or with baseline measurements. SX raised prostaglandin E2 (PGE2), PGF2alpha, and neuropeptide Y (NPY) concentrations in the aqueous humor but reduced these levels in the iris-ciliary body. At 22-24 h after bilateral SX, flurbiprofen (0.03%) significantly (p < 0.001) inhibited the reduction of IOP and the elevation of PGE2 and PGF2alpha levels in the aqueous humor. We conclude that PGs mediate the reduction of IOP at 22-24 h after SX.
Department of Ophthalmology, University of Nebraska Medical Center, Omaha, USA.
Classification:
5 Experimental glaucoma; animal models
11.4 Prostaglandins (Part of: 11 Medical treatment)