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Abstract #5271 Published in IGR 1-2
Effet du Naftidrofuryl (Praxilène?) sur le flux sanguin de la tête du nerf optique du patient glaucomateux(Effects of naftidrofuryl (Praxilène?) on optic nerve head blood flow in glaucomatous patients
Achache F; Titzé P; Movaffaghy A; Mermoud AKlinische Monatsblätter für Augenheilkunde 1999; 214: 260-262
PURPOSE: To evaluate the effects of an S2 specific antiserotonine agent (naftidrofuryl) on the optic nerve head blood flow in glaucomatous patients. Patients and METHOD: 11 glaucomatous subjects were enrolled in the study. After administration of 200 mg naftidrofuryl twice daily for 7 days, values of optic nerve head blood flow (Fonh), velocity and volume were recorded in the temporal rim and cup of the optic nerve head. Blood flow measurements were performed by laser Doppler flowmetry at day 0 and day 7 before and one and two hours after drug administration. RESULTS: Our study showed a significant improvement of perfusion pressure (p=0.02) at day 7 and an increase of mean ophthalmic artery pressure (p=0.03). DISCUSSION: Our preliminary results on a small number of patients and a short follow-up indicate that the use of naftidrofuryl may enhance optic nerve head blood flow in glaucomatous patients. Further studies may confirm these results. (French)
F. Achache, Hôpital Ophtalmique Jules Gonin, Avenue de France 15, CH-1004 Lausanne; Switzerland
Classification:
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
11.7 Treatment of bloodflow (Part of: 11 Medical treatment)
