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Abstract #5353 Published in IGR 1-2
Detection of herpes simplex virus in aqueous humor in iridocorneal endothelial (ICE) syndrome
Groh MJ; Seitz B; Schumacher S; Naumann GOCornea 1999; 18: 359-360
This is the report of a 36-year-old man who was seen with the clinical diagnosis of ICE syndrome in his right eye. On examination, the visual acuity in this eye was 0.6, the intraocular pressure 38 mmHg, the corneal thickness was increased, and the endothelial cell count was decreased. The diagnosis was based on typically altered endothelial cells, iridoschisis and peripheral anterior synechiae. There were no cells in the anterior chamber. Because of the unresponsive intraocular pressure, filtering surgery was performed and aqueous humor was harvested. By means of polymerase chain reaction, a small amount of HSV DNA could be detected. The differential diagnosis in this case was HSV kerato-uveitis. The authors argue that this is very unlikely. They feel that HSV may play a role as a target virus for transferal of unknown genes or gene fragments to corneal endothelial cells, changing their morphological and functional characteristics.
Dr. M.J. Groh, Department of Ophthalmology, University of Erlangen-Nürnberg, Erlangen; Germany
Classification:
9.4.2.1 Iridocorneal endothelial syndrome (ICE, incl. irisatrophy) (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.2 Glaucomas associated with disorders of the cornea, conjunctiva, sclera)