advertisement
Abstract #53583 Published in IGR 15-2
Correlation between optic disc microcirculation in glaucoma measured with laser speckle flowgraphy and fluorescein angiography, and the correlation with mean deviation
Aizawa N; Kunikata H; Yokoyama Y; Nakazawa TClinical and Experimental Ophthalmology 2014; 42: 293-294
Decreased microcirculation of the optic nerve, among other factors including high intraocular pressure (IOP), senescence, and myopia, may contribute to optic nerve damage and lead to the progression of glaucoma. Unfortunately, it is not easy to quantify decreased microcirculation. Historically, it has been associated with the area of filling defects of the optic disc (FD) measured with fluorescein angiography (FA).(1) However, FA examination is invasive, the injection of fluorescein can cause severe complications, such as anaphylactic shock, and the results can be affected by time-dependent changes. Recent innovations in laser speckle flowgraphy (LSFG) have allowed us to monitor changes in the mean blur rate (MBR) of tissue circulation over time, including after pharmacological intervention, at the same site and in the same eye.(2) Furthermore, MBR is correlated with absolute blood flow values measured with hydrogen gas clearance or microspheres.(3, 4) Although it is relative, therefore, MBR should be comparable between eyes. Recently, automatic threshold adjustment allows LSFG to create grayscale images and divide the optic disc into vessel and tissue regions. To determine the comparability of FA and LSFG, we determined the correlation of the relative areas of FD and the region in the optic disc with low circulation density (LD) measured with LSFG to mean deviation (MD) from standard automated perimetry (SAP).
Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Full articleClassification:
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
6.10.2 Posterior segment (Part of: 6 Clinical examination methods > 6.10 Fluorescein (ICG) angiography)
