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Abstract #53623 Published in IGR 15-2

Evaluation of Lamina Cribrosa in Pseudoexfoliation Syndrome Using Spectral-Domain Optical Coherence Tomography Enhanced Depth Imaging

Kim S; Sung KR; Lee JR; Lee KS
Ophthalmology 2013; 120: 1798-1803

See also comment(s) by Nicholas Strouthidis •

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PURPOSE: To evaluate the features of the lamina cribrosa (LC) in pseudoexfoliation glaucoma (PXG) patients using enhanced depth imaging (EDI) of spectral-domain optical coherence tomography (SD OCT). The results were compared with those of patients with primary open-angle glaucoma (POAG). DESIGN: Cross-sectional study. PARTICIPANTS: Patients with PXG (n = 21) and POAG (n = 35) matched for age and visual field mean deviation (VF MD). METHODS: Participants were imaged using SD OCT. Lamina cribrosa thickness (LT) and anterior lamina cribrosa depth (ALD) were determined at 3 areas (mid superior, center, and mid inferior) by 2 examiners using an EDI mode of the optic nerve head. MAIN OUTCOME MEASURES: The LT and ALD were compared between PXG and POAG eyes. RESULTS: Mean ± standard deviation baseline untreated intraocular pressure was not significantly different between the 2 groups (PXG, 18.3±8.2 mmHg; POAG, 15.3±3.4 mmHg; P = 0.310). The mean VF MD was -12.7±9.0 dB in the PXG group versus -11.6±9.1 dB in the POAG group (P = 0.643). When compared with the POAG group, the PXG group demonstrated a significantly thinner LT in all 3 areas and a thinner mean LT (133.4±14.5 μm in the POAG group vs. 121.3±13.0 μm in the PXG group; P<0.001). Anterior lamina cribrosa depth did not demonstrate a significant difference in any of the 3 areas between both groups (mean ALD, 324.3±91.9 μm in the POAG group vs. 358.7±142.7 μm in the PXG group; P = 0.470). Of 21 eyes in the PXG group, 9 eyes demonstrated a unilateral clinical presentation. When we compared the PXG eyes and the apparently normal-looking fellow eyes of those 9 eyes, neither the LT nor ALD demonstrated a significant difference (P = 0.223 and P = 0.079, respectively). CONCLUSIONS: Eyes with PXG demonstrate a thinner LC compared with POAG eyes at similar levels of glaucoma severity. FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.

Department of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea.

Full article

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Classification:

9.4.4.1 Exfoliation syndrome (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.4 Glaucomas associated with disorders of the lens)
2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)
2.3 Sclera (Part of: 2 Anatomical structures in glaucoma)

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