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Abstract #53680 Published in IGR 15-2
Large-area versus small-area application of mitomycin C during trabeculectomy
Matlach J; Panidou E; Grehn F; Klink TEuropean Journal of Ophthalmology 2013; 23: 670-677
PURPOSE: To compare 2 different application methods of mitomycin C (MMC) in patients undergoing trabeculectomy. METHODS: This retrospective trial compared outcomes of 191 eyes that underwent trabeculectomy with small-area (96 eyes; 50.3%) and large-area (95 eyes; 49.7%) MMC application. Main outcome measures were changes in intraocular pressure (IOP), required glaucoma medications, the frequency of complications, and postsurgical interventions. RESULTS: Within both treatment groups, a highly significant IOP reduction was seen during follow-up (p < 0.0001). Statistical analyses revealed a significant difference in IOP between both groups. Patients treated with a larger size of surface area had a higher IOP reduction within the first postoperative year. Choroidal detachment, shallow anterior chamber, and bleb leak were seen more often in the large-area group with more aggressive MMC use. In contrast, complications associated with bleb failure such as bleb scarring were higher in the small-area group. Success rate was higher in the large-area MMC application group after 12 months. CONCLUSIONS: Large-area treatment seems to be a more efficient application method of MMC during trabeculectomy.
Department of Ophthalmology, University of Wuerzburg, Wuerzburg - Germany.
Full articleClassification:
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
