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Abstract #53936 Published in IGR 15-2
Retinal nerve fiber layer thickness measurements by optical coherence tomography in patients with sleep apnea syndrome
Sagiv O; Fishelson-Arev T; Buckman G; Mathalone N; Wolfson J; Segev E; Peled R; Lavi I; Geyer OClinical and Experimental Ophthalmology 2014; 42: 132-138
BACKGROUND: To investigated whether retinal nerve fiber layer abnormalities can be detected in patients with obstructive sleep apnea/hypopnea syndrome with normally appearing optic disc. DESIGN: Observational case-control study. PARTICIPANTS: One hundred and eight consecutive patients with moderate or severe obstructive sleep apnea/hypopnea syndrome as determined by overnight polysomnography and normal looking discs and 108 age matched healthy controls. METHODS: All patients underwent retinal nerve fiber layer examinations by optical coherence tomography using fast retinal nerve fiber layer thickness scan. MAIN OUTCOME MEASURES: Retinal nerve fiber layer thickness. RESULTS: Multivariate regression analysis results showed that the retinal nerve fiber layer was thinner for a patient with obstructive sleep apnea/hypopnea syndrome than that of a normal control in the average by 4.20μm (p<0.003), in the superior quadrant by 4.83μm (p=0.028), and in the inferior quadrant by 5.19μm (p=0.016). Retinal nerve fiber layer thickness did not correlate with the severity of the disease. CONCLUSIONS: RNFL thinning was detected in normal looking discs of patients with advanced OSAHS, but the extent of this thinning did not correlate with the severity of the disease. Longitudinal follow-up is needed to clarify whether RNFL thinning in OSAHS patients with normal clinically appearing optic nerves will eventually lead to glaucoma.
The Bruce Rappaport Faculty of Medicine, The Technion - Israel Institute of Technology, Haifa, Israel.
Full articleClassification:
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)
