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Abstract #53950 Published in IGR 15-2
Anterior Segment Optical Coherence Tomography Parameters in Subtypes of Primary Angle Closure
Guzman CP; Gong T; Nongpiur ME; Perera SA; How AC; Lee HK; Cheng L; He M; Baskaran M; Aung TInvestigative Ophthalmology and Visual Science 2013; 54: 5281-5286
PURPOSE: To compare anterior segment parameters, assessed by anterior segment optical coherence tomography (ASOCT), in subjects categorized as primary angle closure suspect (PACS), primary angle closure (PAC), primary angle closure glaucoma (PACG), and previous acute PAC (APAC); and to identify factors associated with APAC. METHODS: This was a prospective ASOCT study of 425 subjects with angle closure (176 PACS, 66 PAC, 125 PACG, and 58 APAC). Customized software (Zhongshan Angle Assessment Program, Guangzhou, China) was used to measure ASOCT parameters, including angle opening distance (AOD750), trabecular-iris space area (TISA750), anterior chamber depth, width, area and volume (ACD, ACW, ACA, ACV), iris thickness (IT750), iris area (IAREA) and lens vault (LV). Mean differences in anterior segment parameters were evaluated by analysis of covariance (ANCOVA) adjusted for age, gender and pupil diameter. RESULTS: Comparison among the different subgroups showed that ACD, ACA and ACV were smallest, and IT750 thickest in the APAC group compared to the other subgroups (p<0.001). LV was greatest in the APAC group (1218±34µm) followed by PAC (860±31µm), PACG (845±23µm) and PACS (804±19µm) respectively (p=<0.001). While the APAC group had the narrowest angles, the PACS group had the widest (p<0.001 for both AOD750 and TISA750). Logistic regression showed that greater LV (p=<0.001), narrower TISA750 (p=<0.001) and thicker IT750 (p=0.007) were the major determinants of APAC. CONCLUSIONS: Eyes with APAC had the narrowest angles, smallest anterior segment dimensions, thickest iris and largest LV compared with PACS, PAC and PACG. LV, TISA750 and IT750 were the major determinants of APAC.
Singapore Eye Research Institute, Singapore, 168751, Singapore.
Full articleClassification:
9.3.5 Primary angle closure (Part of: 9 Clinical forms of glaucomas > 9.3 Primary angle closure glaucomas)
6.9.2.1 Anterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
