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Abstract #54050 Published in IGR 15-2
Influence on ocular surface and intraocular pressure of switching from preservative-containing to preservative-free carteolol hydrochloride ophthalmic solution
Chikama T; Araie M; Nishida TNippon Ganka Gakkai Zasshi 2013; 117: 419-426
To compare the effect of reducing the ocular surface disorders and the ocular hypotensive effect of preservative-free carteolol hydrochloride ophthalmic solution (PF) with that of preservative-containing carteolol hydrochloride ophthalmic solution(MK) in glaucoma patients. SUBJECTS AND METHODS : After MK and latanoprost ophthalmic solution (XL) were instilled into the eyes of 79 glaucoma patients for a 4-week period, 40 patients were randomly assigned to be switched to a PF group (PF and XL instillation) and 39 patients not to be switched to the PF group (MK and XL instillation) for a 12-week period. Keratoconjunctival epithelium disorder scores and intraocular pressure (IOP) were assessed at baseline, 4 weeks, 8 weeks and 12 weeks. RESULTS : Keratoconjunctival epithelium disorder scores showed no difference at any point in either group. IOP decreased significantly after 4 weeks compared with the baseline and showed the same value at any point in both groups. CONCLUSION : There was no reduction in the ocular surface disorders at any point in either group. IOP decreased significantly in both groups after 4 weeks compared with the baseline, but there was no difference at any point in either group.
Department of Ophthalmology and Visual Science, Hiroshima University Graduate School of Biomedical Sciences, Japan. chikama@hiroshima-u.ac.jp
Classification:
11.16 Vehicles, delivery systems, pharmacokinetics, formulation (Part of: 11 Medical treatment)
