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Abstract #54319 Published in IGR 15-3

Circle- and grid-wise analyses of peripapillary nerve fiber layers by spectral domain optical coherence tomography in early-stage glaucoma

Mayama C; Saito H; Hirasawa H; Konno S; Tomidokoro A; Araie M; Iwase A; Ohkubo S; Sugiyama K; Otani T; Kishi S; Matsushita K; Maeda N; Hangai M; Yoshimura N
Investigative Ophthalmology and Visual Science 2013; 54: 4519-4526

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PURPOSE: To study diagnostic performances of circle- and grid-wise analyses of peripapillary retinal nerve fiber layer thickness (RNFLT) using spectral domain optical coherence tomography (SD-OCT) in early-stage glaucoma. METHODS: Eighty-nine open-angle glaucoma (OAG) eyes (mean deviation: 2.5 ± 1.8 dB) and 89 age-matched normal eyes were studied. Peripapillary RNFLT was analyzed using an SD-OCT raster scan in a 6.0 × 6.0-mm area. Averaged RNFLT was calculated over 0.1 × 0.1-, 0.21 × 0.21-, or 0.42 × 0.42-mm grids in the peripapillary area (grid method), or arcuate sector areas between 2.8- and 4.0-mm diameter circles (annulus method), or along a 3.4-mm diameter circle (circle method). Normative data-based cutoff values for averaged RNFLT and number of abnormal grid locations (grid method) or sectors (annulus or circle method) were varied. RESULTS: The grid method showed the best power of sensitivity/specificity of 0.94/0.96 with any five contiguous 0.21 × 0.21-mm grid locations with a 2.5 percentile cutoff, followed by the annulus method of 0.81/0.98, and the circle method of 0.76/0.97, with 30° sectors. The sensitivity of the grid method was significantly higher than that of the other methods (P < 0.001), whereas the specificity was not. Coefficients of variation and interclass correlation coefficients of intervisit measurements of averaged RNFLT over each 0.21 × 0.21-mm grid were 3.1% to 11.3% and 0.937 to 0.760, respectively, in a separate OAG patient group. CONCLUSIONS: Grid-wise analyses of peripapillary RNFLT for differentiating early-stage glaucoma showed >0.90 sensitivity and ≥0.95 specificity.

Department of Ophthalmology, University of Tokyo Graduate School of Medicine, Tokyo, Japan. cmayama-tky@umin.ac.jp

Full article

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Classification:

6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)

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