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Abstract #54409 Published in IGR 15-3
Neuroprotection of medical IOP-lowering therapy
Pfeiffer N; Lamparter J; Gericke A; Grus FH; Hoffmann EM; Wahl JCell and Tissue Research 2013; 353: 245-251
Intraocular pressure (IOP)-lowering therapy has been shown to arrest or retard the progression of optic neuropathy typical for glaucoma and can, thus, be described as neuroprotective. At present, six classes of medical therapy are employed, namely parasympathomimetics, alpha/beta-sympathomimetics, β-blockers, carbonic anhydrase inhibitors, α2-adrenergic receptor agonists and prostaglandin analogues. For several of these substances, some experimental evidence exists of a possible neuroprotective mechanism, beyond their IOP-lowering activity. β-Blockers are involved in the up-regulation of brain-derived neurotrophic factor (BDNF) and can decrease glutamate-mediated NMDA receptor activation. Not only systemic but also topical carbonic anhydrase inhibitors are able to increase retinal blood flow. α2-Adrenergic receptor agonists can up-regulate the formation of BDNF and anti-apoptotic factors. Prostaglandin analogues increase blood flow to the eye, possibly including the retina. To date, evidence for a neuroprotective effect independent of IOP regulation in human glaucoma is scarce and has only been shown to be likely for the α2-adrenergic receptor agonist, brimonidine.
Department of Ophthalmology, Johannes Gutenberg-University, Langenbeckstrasse 1, 55131, Mainz, Germany. Norbert.Pfeiffer@unimedizin-mainz.de
Full articleClassification:
11.8 Neuroprotection (Part of: 11 Medical treatment)
