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1 General aspects (0)   1.1 Epidemiology (7)   1.2 Population genetics (1)   1.3 Pathogenesis (8)   1.4 Quality of life (5)   1.5 Glaucomas as cause of blindness (3)   1.6 Prevention and screening (14) 2 Anatomical structures in glaucoma (0)   2.1 Conjunctiva (10)   2.2 Cornea (17)   2.3 Sclera (8)   2.4 Anterior chamber angle (8)   2.5 Meshwork (0)     2.5.1 Trabecular meshwork (12)     2.5.2 Schlemms canal (1)     2.5.3 Scleral outlet channels (0)   2.6 Aqueous humor dynamics (0)     2.6.1 Production (0)     2.6.2 Outflow (0)       2.6.2.1 Trabecular meshwork (2)       2.6.2.2 Uveoscleral (2)     2.6.3 Compostion (5)   2.7 Episcleral veins and venous pressure (0)   2.8 Iris (7)   2.9 Ciliary body (1)   2.10 Lens (0)   2.11 Vitreous body (1)   2.12 Choroid, peripapillary choroid, peripapillary atrophy (5)   2.13 Retina and retinal nerve fibre layer (42)   2.14 Optic disc (26)   2.15 Optic nerve (2)   2.16 Chiasma and retrochiasmal central nervous system (7)   2.17 Stem cells (2)   2.20 Other (0) 3 Laboratory methods (0)   3.1 Microscopy (3)   3.2 Electron microscopy (0)   3.3 Immunohistochemistry (4)   3.4 Molecular genetics (0)     3.4.1 Linkage studies (0)     3.4.2 Gene studies (40)   3.5 Molecular biology incl. 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Miscellaneous (17)

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Abstract #54548 Published in IGR 15-3

Screening for glaucoma using GDx-VCC in a population with ≥1 risk factors

Li G; Fansi AK; Harasymowycz P
Canadian Journal of Ophthalmology 2013; 48: 279-285

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OBJECTIVE: To estimate the diagnostic accuracy of the GDx-VCC for glaucoma screening in a population with ≥1 risk factors for glaucoma. DESIGN: Cross-sectional evaluation of a diagnostic test for screening. PARTICIPANTS: Two hundred forty-seven community-based volunteer participants with risk factors for glaucoma. METHODS: The peripapillary retinal nerve fibre layers (RNFL) of participants' eyes were scanned using the GDx-VCC. Based on an ophthalmologic examination and frequency doubling perimetry, eyes were classified into 4 categories: normal, possible glaucoma, probable glaucoma, and definitive glaucoma. The sensitivities, specificities, positive and negative predictive values, and positive and negative likelihood ratios of the RNFL parameters were calculated. RESULTS: The right eyes were retained for analyses. After excluding 5 eyes because of missing data and 23 eyes because of poor scan quality, the data of 219 right eyes were analyzed. Four eyes had definitive glaucoma. The best performing parameter was the nerve fibre indicator using a cutoff of 35 with a sensitivity of 75% (95% CI 19.4-99.4) at a specificity of 95% (95% CI 91.3-97.3), a positive predictive value of 25 (95% CI 4.3-48.1), a negative predictive value of 99 (95% CI 97.5-100.0), a positive likelihood ratio of 16 (95% CI 6.69-32.5), and a negative likelihood ratio of 0.20 (95% CI 0.05-1.44). CONCLUSIONS: The GDx-VCC has inadequate sensitivity for screening of definitive glaucoma.

Ophthalmology Research Unit, Maisonneuve-Rosemont Hospital, University of Montreal, Montreal, Que., Canada. gisele.li@umontreal.ca

Full article

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Classification:

1.6 Prevention and screening (Part of: 1 General aspects)
9.2.2 Other risk factors for glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)

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