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Abstract #54679 Published in IGR 15-3

Evaluation of brimonidine-timolol fixed combination in patients of primary open-angle glaucoma

Joshi SR; Akat PB; Ramanand JB; Ramanand SJ; Karande VB; Jain SS
Indian Journal of Ophthalmology 2013; 61: 765-767

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The aim of present study was to compare the efficacy and safety of fixed combination of brimonidine and timolol with individual components used as monotherapy in patients of primary open angle glaucoma. Patients were randomly assigned to receive brimonidine or timolol or brimonidine-timolol fixed combination, with 30 patients in each group. The mean reduction in intraocular pressure in brimonidine, timolol, and brimonidine-timolol group were 4.29 ± 1.97 mm Hg, 4.34 ± 1.21 mm Hg, and 5.54 ± 1.87 mm Hg respectively at 2 weeks and 4.86 ± 1.16 mm Hg, 5.42 ± 1.50 mm Hg, and 7.36 ± 2.58 mm Hg respectively at 6 weeks. When values of mean reduction in intraocular pressure were compared between brimonidine-timolol fixed combination with brimonidine and timolol, it was found to be statistically significant (P < 0.05) at 2 weeks and highly significant (0.001) at 6 weeks. The overall frequency of adverse effects was similar in all three groups.

Department of Pharmacology, Government Medical College, Miraj, Maharashtra, India.

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Classification:

11.13.3 Betablocker and brimonidine (Part of: 11 Medical treatment > 11.13 Combination therapy)

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