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Abstract #54687 Published in IGR 15-3
Fibronectin and insulin-like growth factor-1 in pathogenesis of open-angle and pseudoexfoliative glaucoma
Georgian Medical News 2013; 0: 13-17
The aim of the present investigation was to study the role of fibronectin and insulin-like growth factor-1 (IGF-1) in pathogenesis of primary open-angle and pseudoexfoliative glaucoma. Immune enzyme analysis was performed on aqueous humour of 480 patients with complicated cataracts on the background of primary open-angle and pseudoexfoliative glaucoma. The aqueous humour of patients with senile cataracts was used as control. The content of fibronectin and IGF-1 in aqueous humour was determined using appropriate kits (DRG-International Inc., USA) in the absorbance wavelength range 420-450 nm. The obtained results were analyzed using Student's criteria and application of SPSS-13/80. Relatively high levels of fibronectin and IGF-1 were recorded in aqueous humour of patients with complicated cataracts (cataracts on the background of open-angle and pseudoexfoliative glaucoma), as compared to indices of both cytokines in the aqueous humour of control group patients. In mechanisms of eye drainage function impairment and intraocular pressure increase an important role belongs to in situ (i.e. in the eye membranes) produced fibronectin and IGF-1.
Yerevan State Medical University, Scientific-Research Center, Yerevan; 2Ophthalmology Department; "Shengаvit" Medical Center, Yerevan, Armenia.
Classification:
9.4.4.1 Exfoliation syndrome (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.4 Glaucomas associated with disorders of the lens)
1.3 Pathogenesis (Part of: 1 General aspects)
2.6.3 Compostion (Part of: 2 Anatomical structures in glaucoma > 2.6 Aqueous humor dynamics)
