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Abstract #54720 Published in IGR 15-3
Association of single-nucleotide polymorphism rs4236601 near caveolin 1 and 2 with primary open-angle glaucoma: a meta-analysis
Huang W; Wang W; Zhou M; Zhang XClinical and Experimental Ophthalmology 2014; 42: 515-521
BACKGROUND: To clarify the effects of a single-nucleotide polymorphism, rs4236601[A] near caveolin 1 and 2, on primary open-angle glaucoma (POAG) risk. DESIGN: Meta-analysis. PARTICIPANTS: A total of 5774 patients and 40 598 controls from previously reported case-control studies were included. METHODS: A comprehensive literature search was performed for studies published up to April 2013. SUMMARY: odds ratios (ORs) and 95% confidence intervals (CI) were calculated, employing random- or fixed-effects models according to between-study heterogeneity. Publication bias of the literature articles was evaluated using funnel plots and Egger's test. MAIN OUTCOME MEASURES: OR for the effects of rs4236601[A] on POAG risk. RESULTS: Five eligible studies were included in this meta-analysis. Overall, the association between rs4236601[A] and risk for POAG was statistically significant (OR = 1.23, 95% CI 1.12-1.34; P < 0.001). Stratified analyses showed that the association between rs4236601[A] and POAG risk was statistically significant in Caucasians (OR = 1.25, 95% CI 1.18-1.33; P < 0.001) and Asians (OR = 3.33, 95% CI 1.56-7.08; P = 0.003) but not in Africans. Increased risks were found in age- and sex-matched studies (OR = 1.26, 95% CI 1.14-1.40; P < 0.001), but no statistically significant risk was found in unmatched studies. CONCLUSIONS: This meta-analysis suggests that rs4236601[A] is associated with increased risk for POAG in Caucasian and Asian populations. However, well-designed gene-environment interaction studies and studies including more ethnic groups are required in further investigations.
Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, China.
Full articleClassification:
3.4.2 Gene studies (Part of: 3 Laboratory methods > 3.4 Molecular genetics)
