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Abstract #54778 Published in IGR 15-3

Topographic optic disc changes after successful trabeculectomy evaluated using spectral domain optical coherence tomography

Russo A; Katsanos A; Riva I; Floriani I; Biagioli E; Quaranta L
Journal of Ocular Pharmacology and Therapeutics 2013; 29: 870-875

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PURPOSE: To investigate topographic optic disc changes after surgical intraocular pressure (IOP) reduction in adults with open angle glaucoma (OAG). METHODS: Optic discs of patients with advanced primary open angle or exfoliation glaucoma were imaged using optical coherence tomography within 1 week before trabeculectomy. Patients were rescanned 1 week, 1 month, and 1 year after surgery. Maximum cup depth (MCD), and average cup depth (ACD) were calculated. RESULTS: Twenty-two eyes from 20 patients (age, 70.5±10.6 years; average mean defect of visual field, -15.0±9.8 dB) were followed up for 1 year. The IOP decreased from 22.1±2.8 mmHg at baseline to 11.5±2.6 mmHg 1 year following surgery (P<0.001). One-week and 1-month postoperative IOPs were 11.2±2.8 and 11.2±3.5 mmHg, respectively (P<0.001). Compared to the baseline values (356±172 μm), postoperative ACD showed a significant decrease at 1 week (312±164 μm; P<0.001) and 1 month (338±175 μm; P=0.007) after surgery, but not at 1 year (339±176 μm; P=0.354). Similarly, MCD significantly decreased from baseline (477±190 μm) 1 week (431±203 μm; P=0.029) and 1 month (448±198 μm; P=0.047) after the surgery, but not after 1 year (479±188 μm; P=1.0). CONCLUSIONS: Trabeculectomy reduces IOP in eyes with advanced OAG, which induces topographic optic disc changes. Such optic disc changes became less pronounced over time and were no longer detectable 1 year after surgery.

1 Centre for the Study of Glaucoma, University of Brescia , Brescia, Italy .

Full article

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Classification:

12.8.1 Without tube implant (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)

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