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Abstract #54826 Published in IGR 15-3
Correlation of Magnetic Resonance Imaging optic nerve parameters to Optical Coherence Tomography and the visual field in glaucoma
Omodaka K; Murata T; Sato S; Takahashi M; Tatewaki Y; Nagasaka T; Doi H; Araie M; Takahashi S; Nakazawa TClinical and Experimental Ophthalmology 2014; 42: 360-368
BACKGROUND: To determine the viability of using MRI measurement of optic nerve morphology as an objective analysis of glaucomatous damage. DESIGN: Retrospective study conducted at Tohoku University Hospital. PARTICIPANTS: Thirty-eight eyes of 19 patients with open angle glaucoma. METHODS: Patients were scanned with T2-weighted and 3-T diffusion tensor MRI, and parameters of the optic nerve, including fractional anisotropy, apparent diffusion coefficient, and cross-sectional area, were determined. Conventional parameters of glaucomatous damage, including circumpapillary and macular retinal nerve fiber layer thickness, and mean deviation and average total deviation of the central 16 test points from the Humphrey Field Analyzer, were then compared to the MRI-derived parameters. Spearman's coefficient of correlation was calculated to determine the significance of the correlation. MAIN OUTCOME MEASURE: Correlation coefficient between the MRI parameters and the parameters of glaucomatous damage. RESULTS: Mean deviation was significantly correlated with all MRI parameters (fractional anisotropy: r = 0.53, apparent diffusion coefficient: r = -0.44, cross-sectional area: r = 0.70). Circumpapillary retinal nerve fiber layer thickness was significantly correlated with fractional anisotropy (r = 0.60) and cross-sectional area (r = 0.47), but not apparent diffusion coefficient (r = -0.29). Central macular function and macular retinal nerve fiber layer thickness were also significantly correlated with MRI parameters. CONCLUSIONS: Optic nerve MRI parameters were significantly correlated to glaucomatous damage. MRI analysis of the optic nerve may thus have value as an objective instrument to assess glaucomatous degeneration, including the function of the macula.
Department of Ophthalmology, Tohoku University Graduate School of Medicine.
Full articleClassification:
2.15 Optic nerve (Part of: 2 Anatomical structures in glaucoma)
6.30 Other (Part of: 6 Clinical examination methods)
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
6.6.2 Automated (Part of: 6 Clinical examination methods > 6.6 Visual field examination and other visual function tests)
