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Abstract #54853 Published in IGR 15-3
Dual leucine zipper kinase as a therapeutic target for neurodegenerative conditions
Ferraris D; Yang Z; Welsbie DFuture medicinal chemistry 2013; 5: 1923-1934
Dual leucine zipper kinase (DLK) is a serine/threonine protein kinase that is a member of the mixed lineage kinase subfamily. Mixed lineage kinases are upstream MAP3Ks that activate the JNK pathway. DLK is primarily responsible for activating JNK and mediating the apoptotic stress response in various cell types, specifically neurons. Inhibition and knockdown of DLK has been demonstrated to have neuroprotective effects in cellular and animal models of Alzheimer's disease, glaucoma, Parkinson's disease and other neurodegenerative conditions. Several series of ATP-binding site inhibitors have been identified through profiling efforts providing launch points for future medicinal chemistry programs.
John Hopkins University Brain Science Institute, 855 North Wolfe Street, Baltimore, MD 21205, USA.
Full articleClassification:
11.8 Neuroprotection (Part of: 11 Medical treatment)
3.6 Cellular biology (Part of: 3 Laboratory methods)
