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Abstract #5493 Published in IGR 1-2
Effect of TGF- beta sub(1) blocker Tranilast on filtering blebs after glaucoma surgery
Chihara E; Ochiai H; Dong TFolia Ophthalmologica Japonica / Nihon Ganka Kiyo 1999; 50: 260-266
We conducted a prospective, randomized, double-blinded study to test the hypothesis that the transforming growth factor (TGF- beta sub(1)) suppressor Tranilast will inhibit postoperative fibrosis and enhance regeneration of the conjunctival epithelium and facilitate formation of a large and functional filtering bleb after glaucoma surgery. The study was conducted in 33 eyes of 33 patients with medically uncontrollable primary open angle glaucoma (32 eyes) or pseudoexfoliation syndrome (1 eye). Postoperatively, 17 eyes were treated with a regimen that included topical 0.5% Tranilast and the 16 control eyes were treated with a regimen that included the vehicle buffer solution. Patients underwent trabeculectomy and were examined periodically, including evaluation of clinical features of the bleb and measurement of intraocular pressure (IOP). Postoperative IOP was always lower in Tranilast- treated eyes, and IOP at 1 month postoperatively was statistically significantly lower in Tranilast-treated eyes (p=0.027). An excessive bleb (one that overhung the cornea) was significantly more frequently seen in eyes treated with Tranilast (p=0.017). The transparency of the bleb was not significantly different in Tranilast-treated eyes (p=0.115) and no serious complications were noted in Tranilast-treated eyes. Tranilast facilitates formation of large filtering blebs and reduce lOP after glaucoma surgery.LA: Japanese
Dr. E. Chihara, Sensho-Kai Eye Institute, 1-6 Hiraki-cho, Uji 611-0026; Japan
Classification:
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
