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Abstract #5507 Published in IGR 1-2
Effects of subconjunctival injection of mitomycin-C on iridial circulation in rabbits
Tomidokoro A; Araie M; Tamaki Y; Muta KCurrent Eye Research 1999; 19: 197-200
PURPOSE: To determine the effects of a subconjunctival injection of mitomycin C (MMC) on iridial circulation in rabbits. METHODS: Dutch rabbits anesthetized with pentobarbital received a 0.2-ml subconjunctival injection of 0.4 mg/ml or 0.1 mg/ml MMC; the contralateral eye received 0.2 ml physiological saline. Intraocular pressure (IOP) and NBiris, a quantitative index of iridal tissue blood velocity, were measured up to 24 hours after treatment. RESULTS: At a dosage of 0.4 mg/ml MMC, NBiris obtained from the iridial area adjacent to the injection site decreased significantly by 13.6% and 18.6% at 1 and 2 hours (p=0.03, 0.01, respectively) after treatment; NBiris obtained on the contralateral side of the injection showed no significant change. In eyes treated with 0.1 mg/ml MMC, NBiris did not change significantly. The mean IOP was significantly lower by 3.1, 3.0, and 1.8 mmHg at 6, 12, and 24 hours after the 0.4 mg/ml injection of MMC compared with the fellow eyes (p=0.03, 0.01, and 0.03, respectively), and the IOP decreased by 1.7 mmHg at 4 hours in the eyes treated with 0.1 mg/ml MMC (p=0.04). CONCLUSIONS: Subconjunctival injections of 0.2 ml of 0.5 mg/ml MMC caused not only a significant decrease of IOP but also a transient but significant effect on iridal circulation.
A. Tomidokoro, Eye Clinic, Omiya Red Cross Hospital, Saitama; Japan
Classification:
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
