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Abstract #55362 Published in IGR 15-4
Retinal nerve fibre layer cross-sectional area, neuroretinal rim area and body mass index
Jonas JB; Nangia V; Gupta R; Agarwal S; Matin A; Khare A; Bhate K; Sinha A; Bhojwani K; Kulkarni M; Panda-Jonas SActa Ophthalmologica 2014; 92: e194-e199
PURPOSE: To examine associations between body mass index, neuroretinal rim area and retinal nerve fibre layer cross-sectional area (RNFLCRA) in a population-based setting. METHODS: The Central India Eye and Medical Study is a population-based study performed in a rural region of Central India. The study included 4711 subjects (aged 30 + years). A detailed ophthalmic and medical examination was performed. Inclusion criteria for this study were an intra-ocular pressure ≤21 mmHg, open anterior chamber angles and an axial length ≤26.5 mm. Neuroretinal rim area and RNFLCRA were measured by confocal laser scanning tomography. RESULTS: The study included 3959 subjects fulfilling the inclusion criteria. Larger neuroretinal rim area (mean: 1.63 ± 0.32 mm(2) ) was significantly (p = 0.004) associated with a higher body mass index after adjusting for larger disc area (p < 0.001), younger age (p < 0.001), lower intraocular pressure (p < 0.001), and hyperopic refractive error (p < 0.001). Larger retinal nerve fibre layer cross-sectional area (mean:1.29 ± 0.39 mm(2) ) was significantly associated with higher body mass index (p = 0.001) after adjusting for younger age (p < 0.001), shorter axial length (p < 0.001), larger optic disc area (p < 0.001), taller body height (p < 0.001) and male gender (p = 0.04). CONCLUSIONS: In a rural Central Indian population, neuroretinal rim area and RNFLCRA as surrogates of the optic nerve fibres were related to a higher body mass index. Because body mass index is associated with cerebrospinal fluid pressure, the higher cerebrospinal fluid pressure may be associated with a larger neuroretinal rim area. It may vaguely point towards an association between cerebrospinal fluid pressure and glaucomatous optic neuropathy.
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Classification:
9.2.2 Other risk factors for glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)
2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)